Zionist Regime Health Minister Yaakov Litzman and his wife tested positive for the novel coronavirus.
In a statement, the Health Ministry said the 71-year-old official and his wife are feeling well as they receive medical care and will remain in isolation.
Prime Minister Benjamin Netanyahu was informed of the development, the statement added.
Litzman, the most senior Zionist official to be diagnosed with the virus, will continue to carry out his duties from home.
In a related development, the head of the Israeli spy agency Mossad entered quarantine due to his having held meetings with Litzman, according to the Israeli Broadcast Authority.
The death toll from the novel coronavirus has risen to 31 in Israel, according to the Health Ministry.